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Monday, February 13

Crafting Smaller, Faster Technologies
The decreasing size and increasing speed of analytic and other tools are helping researchers work more efficiently and productively.
Link to Article
Drug Discovery and Development

Modeling Success in PK/PD Testing
A few years ago, there were many failures in phase III trials due to suboptimal dosing. PK/PD modeling tools are helping change that.
Link to Article
Drug Discovery and Development

Generic Threats Loom For King Pharmaceuticals

Health Affairs Sunday Health Policy Update - February 12, 2006
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Sunday
Health Policy UpDate February
12, 2006 |


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New
postings and analysis from Health
Affairs,
the leading journal of health policy. Health
Affairspublishes
new research each week online at www.healthaffairs.org.
For more information, contact Chris Fleming at
301-347-3944.
Spending
Increases Not Responsible for Improved Heart Attack
Outcomes http://content.healthaffairs.org/cgi/content/abstract/hlthaff.25.w34 |
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In
an article published Feb. 7 on the Health Affairs Web site,
Dartmouth researchers Jonathan Skinner, Douglas Staiger, and
Elliott Fisher challenge the conventional wisdom that
growing health care costs are paying for new treatments and
reduced mortality. The Dartmouth trio found that the factors
fueling improvement in outcomes for heart attack patients
from 1986 through 2002 were not the factors that fueled
increases in costs, and much of the improvement occurred in
U.S. regions exhibiting below-average growth in
spending.
You can also
read perspectives on the Dartmouth study by David Cutler and
Alan Garber.http://content.healthaffairs.org/cgi/content/abstract/hlthaff.25.w48 http://content.healthaffairs.org/cgi/content/abstract/hlthaff.25.w51 |
For
Surgeries, Physician-Owned Cardiac Hospitals Affect Where,
Not Who http://content.healthaffairs.org/cgi/content/abstract/25/1/119 |
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Physician-owned
cardiac specialty hospitals take market share from community
hospitals, but they don’t appreciably increase the overall
number of, or severity mix among, people receiving cardiac
surgery, say Jeffrey Stensland and Ariel Winter in the
January/February Health
Affairs.
This could be because surgery is less discretionary than
services such as imaging studies and laboratory tests, where
physician ownership does increase usage. Or, the researchers
warn, it could be because the arms race between cardiac and
community hospitals has only just
begun. |
Changing
Physician Payment Incentives Entails Complex
Trade-Offs http://content.healthaffairs.org/cgi/content/abstract/25/1/219 |
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In
a report from the field in the January/February Health
Affairs,
Nora Super reminds us how pervasively financial incentives
can affect physician behavior and how hard it is to say what
the "right" incentives are. As Cincinnati Group Health
Associates has moved from capitation to fee-for-service
payment, GHA physicians have grown more willing to schedule
unnecessary office visits and order unnecessary tests. On
the other hand, the group now favors sicker patients over
soccer moms. GHA physicians say they now have more incentive
to get preventive care to those with chronic diseases,
although that may be because capitation never put GHA at
risk for hospital costs.
Print
editions of the January/February issue on "U.S. Hospitals:
Mission Vs. Market" may be ordered for $35 each from
Health
Affairs'
Customer Service at 301-347-3900 or online athttp://www.healthaffairs.org/1330_issue.php |
ABOUT
HEALTH
AFFAIRS:
Health
Affairs,
published by Project HOPE, is the leading journal of health
policy. The peer-reviewed journal appears bimonthly in print
with additional online-only papers published weekly as
Health
Affairs
Web Exclusives at www.healthaffairs.org.
The full text of each Health
Affairs
Web Exclusive is available free of charge to all Web site
visitors for a two-week period following posting, after
which it switches to pay-per-view for nonsubscribers. The
abstracts of all articles are free in perpetuity. Web
Exclusives are supported in part by a grant from the
Commonwealth Fund. SUBSCRIBE
Subscribe
today for full online access to Health
Affairs--"the
bible of health policy" (Washington Post, January 12,
2005). FREE
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RFID production to increase 25-fold by 2010
According to a new report RFID production is to increase 25-fold in four years, buoyed on by the scramble by pharmaceutical manufacturers to comply with the new RFID Certification program, which aims to synchronise the industry’s transition to RFID technology.
Link to Article
In-PharmaTechnologist.com

Africa's Polio Efforts Aiding Bird Flu Fight
by
Lyle
on Mon 13 Feb 2006 03:44 PM EST
Africa's response to the first appearance of H5N1 bird flu on the continent may be aided by its fight against an entirely unrelated infection -- polio.
Link to Article
WashingtonPost.com

Bird Flu Spreads to European Union for First Time
by
Lyle
on Mon 13 Feb 2006 03:43 PM EST
The bird flu virus has been found in wild birds in Italy and Greece, the first time it has been detected in the European Union.
Link to Article
NYTimes.com

Researchers Race to Boost Supply of Bird Flu Vaccine
by
Lyle
on Mon 13 Feb 2006 03:42 PM EST
Additives Studied as Way to Help Fight Potential Pandemic
Link to Article
WashingtonPost.com

Spread of Bird Flu Boosts Pandemic Chances
by
Lyle
on Mon 13 Feb 2006 03:41 PM EST
UNITED NATIONS (AP) -- The spread of bird flu from Asia to eastern Europe and now west Africa has increased the chance the virus will mutate and set off a pandemic, the U.N. bird flu chief said.
Link to Article
NYTimes.com

The second wave in kinase cancer drugs
by
Lyle
on Mon 13 Feb 2006 03:37 PM EST
Cancer drugs targeting signaling pathways have been hampered by problems of efficacy and tumor resistance. Will the next generation of kinase inhibitors fare better than the first? Ken Garber investigates.
Link to Article
Nature Biotechnology

GEN's Sticky Ends Online For February 8, 2006
by
Lyle
on Mon 13 Feb 2006 03:29 PM EST
ACT Launches Research Laboratory in California
Support for stem cell research drives company's move. Full Story
Amgen Expands Manufacturing Capability in Puerto Rico
Company cites rising demand for products as key in decision to expand. Full Story
Cambrex BioScience Walkersville to Purchase Cutanogen
Acquisition enhances wound-care franchise. Full Story
CureVac Raises 22 Million €
Investment from SAP founder will push its main product through Phase II trial. Full Story
GlycoGenesys Reports Chapter 11 Filing, Reduction in Work Force, and Management Changes
Company reduces expenses to pursue strategic alternatives while maintaining multiple myeloma trial. Full Story
Sigma-Aldrich Launches Lentiviral shRNA Gene Family Set
Target set can be used to create a stable knockdown in mammalian cells. Full Story
Vaccine Protects Children from Rotavirus Infection
An estimated 440,000-600,000 childhood deaths worldwide each year attributed to the infection. Full Story
www.genengnews.com

Rapid Microbiological Methods for a New Generation
by
Lyle
on Mon 13 Feb 2006 02:16 PM EST
These are exciting times, as 19th-century microbiological methods make way for rapid detection, quantification and characterization technologies.
Link to Article
PharmaManufacturing.com

The Human Genome Project +5
by
Lyle
on Mon 13 Feb 2006 02:13 PM EST
The five years since the draft of the human genome was published have been productive but bumpy. What will the next five be like?
Link to Article
The-Scientist.com
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